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. 2016 Apr 7;5:15. doi: 10.1186/s40169-016-0092-7

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© Pule et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Time-dependent gene expression changes in K562 cells treated with hydroxyurea Hydroxyurea induced inverse time-dependent sigmoidal expression of BCL11A and HBG-1 (HbF) with the highest fold increase in HbF corresponding to the lowest BCL11A expression between 6 and 12 h after HU treatment. KLF-1, an activator of BCL11A, also followed a similar trend, lowest after 12 h of HU treatment. GATA-1 was also down-regulated at the same time point as well as the negative regulator, MYB. * Significant difference, p < 0.05