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. 2016 Apr 7;5:15. doi: 10.1186/s40169-016-0092-7

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© Pule et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Hydroxyurea-induced gene expression changes in ex vivo derived erythroid cells. The gene expression profiles of primary erythroid lines after HU treatment for 6 h. Although the expected inter-individual variation in expression was observed, there were several common trends such the low BCL11A, KLF-1 and MYB; and significant upregulation of HbF expression. HBB (β-globin) expression was always associated with BCL11A, which is expected given the role of this transcription factor in the “fetal switch”. * Significant difference, p < 0.05