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. 2016 Apr 7;5:15. doi: 10.1186/s40169-016-0092-7

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© Pule et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — Hydroxyurea mechanisms of HbF induction: regulators and miRNAs mediated actions. Proposed HU-induced miRNAs-mediated mode of indirect HbF regulation through critical regulators (MYB/KLF-1/BCL11A) and possibly directly modulating HbF