Table 8. Differences between the IASLC/ITMIG TNM staging proposal categories.
| HR vs. adjacent TNM staging category | CIR, R0 (67/1,060)* |
OS, R0 (23/1,085)* |
OS, any R (39/1,198)* |
|||||
|---|---|---|---|---|---|---|---|---|
| HR | P | HR | P | HR | P | |||
| II vs. I | 0.159 | 0.000 | 0.544 | 0.558 | 1.497 | 0.696 | ||
| IIIa vs. I | 5.235 | 0.000 | 2.926 | 0.028 | 2.207 | 0.080 | ||
| IIIb vs. I | — | — | — | — | 16.665 | 0.000 | ||
| IVa vs. I | — | — | — | — | 8.806 | 0.000 | ||
| IVb vs. I | — | — | — | — | 17.847 | 0.000 | ||
| IIIa vs. II | 1.022 | 0.963 | 1.461 | 0.726 | 1.469 | 0.720 | ||
| IIIb vs. II | — | — | — | — | 11.282 | 0.030 | ||
| IVa vs. II | — | — | — | — | 5.787 | 0.109 | ||
| IVb vs. II | — | — | — | — | 12.108 | 0.024 | ||
| IIIb vs. IIIa | — | — | — | — | 8.088 | 0.001 | ||
| IVa vs. IIIa | — | — | — | — | 4.209 | 0.015 | ||
| IVb vs. IIIa | — | — | — | — | 8.616 | 0.000 | ||
| IVa vs. IIIb | — | — | — | — | 0.515 | 0.323 | ||
| IVb vs. IIIb | — | — | — | — | 0.920 | 0.901 | ||
| IVb vs. IVa | — | — | — | — | 1.872 | 0.322 | ||
Hazard ratios and statistical differences (χ2) by Cox proportional hazards regression models, adjusted by diagnosis. *, number of events/total number of patients in entire data set for the particular analysis. IASLC, the International Association for the Study of Lung Cancer; ITMIG, the International Thymic Malignancies Interest Group; CIR, cumulative incidence of recurrence; OS, overall survival; R0, complete resection; HR, hazard ratio.