Table 3.
Analysis of copeptin, growth hormone (GH), ACTH, cortisol, and glucose secretion in relation to body mass index (BMI) during glucagon stimulation test (Group 1 & 2, i.e., all subjects who passed glucagon stimulation test, n = 61)—comparison of the subjects with the lowest BMI quartile (BMI <20.82 kg/m2) versus those with the highest quartile (BMI >27.57 kg/m2)
| Parameter | Time | BMI <20.82 kg/m2 | BMI >27.57 kg/m2 | p | ||
|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | |||
| Copeptin [pmol/l] | 0′ | 7.9 | 8.7 | 5.0 | 4.0 | 0.418 |
| 60′ | 6.7 | 6.5 | 4.3 | 3.0 | 0.275 | |
| 90′ | 6.6 | 6.4 | 3.8 | 2.5 | 0.110 | |
| 120′ | 10.1 | 10.1 | 4.0 | 4.0 | 0.022 | |
| 150 | 15.5 | 20.4 | 5.2 | 5.2 | 0.018 | |
| 180′ | 15.9 | 16.0 | 6.2 | 5.2 | 0.036 | |
| GH [ng/ml] | 0′ | 1.8 | 2.0 | 2.0 | 7.1 | 0.049 |
| 60′ | 2.3 | 4.2 | 2.9 | 6.1 | 0.048 | |
| 90′ | 3.3 | 3.1 | 2.7 | 5.6 | 0.054 | |
| 120′ | 9.5 | 7.0 | 3.5 | 5.6 | 0.003 | |
| 150′ | 12.4 | 9.5 | 3.1 | 4.7 | 0.002 | |
| 180′ | 7.0 | 5.1 | 3.5 | 3.6 | 0.050 | |
| ACTH [pg/ml] |
0′ | 21.7 | 10.2 | 34.7 | 23.0 | 0.145 |
| 60′ | 17.2 | 15.0 | 17.2 | 8.5 | 0.345 | |
| 90′ | 14.7 | 8.4 | 15.8 | 9.4 | 0.710 | |
| 120′ | 16.7 | 8.7 | 19.5 | 13.1 | 0.577 | |
| 150′ | 27.1 | 16.8 | 24.7 | 16.6 | 0.676 | |
| 180, | 29.6 | 21.8 | 29.5 | 30.7 | 0.722 | |
| Glucose [mg/dl] | 0′ | 78.6 | 8.7 | 82.7 | 7.4 | 0.132 |
| 60′ | 111.0 | 40.0 | 137.6 | 45.8 | 0.058 | |
| 90′ | 85.1 | 29.7 | 116.8 | 39.2 | 0.003 | |
| 120′ | 67.6 | 9.5 | 92.2 | 27.2 | 0.001 | |
| 150′ | 62.6 | 9.6 | 77.0 | 19.1 | 0.004 | |
| 180′ | 67.8 | 11.0 | 70.5 | 12.9 | 0.844 | |
| Copeptin (area under the curve) | 1536.0 | 1965.0 | 978.3 | 1034.7 | 0.046 | |
| ACTH (area under the curve) | 4152.7 | 2499.7 | 5031.1 | 3132.6 | 0.496 | |
| GH (area under the curve) | 924.6 | 726.0 | 361.8 | 395.5 | 0.006 | |
| Glucose (area under the curve) | 12713.1 | 1257.2 | 14179.1 | 2303.3 | 0.054 | |
Statistical significance values are highlighted in bold for better visibility