Table 2.
Histological features of diffuse-type gastric cancers with or without RHOA mutation
| Findings | RHOA mutated (n = 22) | RHOA wild type (n = 65) | P |
|---|---|---|---|
| Histological type | |||
| Pure poorly cohesive carcinoma | 6 (27 %) | 30 (46 %) | 0.1201 |
| Poorly cohesive plus other types | 16 (73 %) | 35 (54 %) | |
| Presence of tubular component | 16 (73 %) | 33 (51 %) | 0.0862 |
| Intramucosal area | 16 (73 %) | 28 (43 %) | 0.0254 |
| Submucosal or deeper area | 10 (53 %) | 27 (46 %) | 0.7922 |
| Presence of mucinous component | 3 (14 %) | 9 (14 %) | 1.0000 |
| Stromal features | 0.3575 | ||
| Desmoplastic | 18 (82 %) | 58 (89 %) | |
| Inflammatory | 9 (41 %) | 13 (20 %) | |
| Myxoid | 5 (23 %) | 14 (22 %) | |
| Normal | 4 (18 %) | 6 (9 %) | |
| Lymphatic invasion | |||
| Negative or minimal | 12 (55 %) | 39 (60 %) | 0.8028 |
| Moderate or marked | 10 (45 %) | 26 (40 %) | |
| Vascular invasion | |||
| Negative or minimal | 13 (59 %) | 36 (55 %) | 0.8082 |
| Moderate or marked | 9 (41 %) | 29 (45 %) | |
| Carcinomatous lymphangiosis | 4 (18 %) | 8 (12 %) | 0.4893 |
| Perineural invasion | 7 (32 %) | 31 (48 %) | 0.2226 |
| Growth pattern | |||
| Intramucosal area | |||
| Permeative | 13 (59 %) | 19 (29 %) | 0.0202 |
| Expansile | 9 (41 %) | 46 (71 %) | |
| Submucosa or deeper area | |||
| Infiltrative | 19 (100 %) | 58 (98 %) | 1.0000 |
| Expanding | 0 | 1 (2 %) | |
| Ratio of deeply invasive to intramucosal size | |||
| ≥1.45a | 6 (32 %) | 34 (58 %) | 0.0482 |
| <1.45 | 13 (68 %) | 25 (42 %) | |
aMedian of the ratios of deeply invasive to intramucosal size