Fig. 2.

Interactomes of mismatch repair proteins. (A) Cellular function annotation of all HCIPs using gene ontology analysis. The function pathways with significant multiple testing p value were shown in the histogram. (B) Network integration and analysis of all HCIPs of DNA MMR proteins were conducted using cytoscape software. In this network, the cycles with blue color are MutS complexes, and the red ones are MutL complexes, and the green ones are MSH4-MSH5 complex. The purple cycle EXO1 interacts with both MutS and MutL complexes. The yellow one is MLH3, which indicates no strong binding between MLH3 and other MMR proteins found in this study. (C) Principal component analysis of the HCIPs and the corresponding PSMs of MMR protein interactomes. The ratios for x and y axis indicate the percentage of variance explained by these two principal components.