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. 2016 Apr 7;23:17. doi: 10.1051/parasite/2016017

Table 2.

IC50 values for ROP19 binding to MHC class II molecules obtained using the immune epitope databasea.

MHC II Alleleb Start-Stopc
Percentile Rankd
SAG1 ROP19 SAG1 ROP19
HLA-DRB1*01:01 12–26 5–19 0.88 0.04
35–49 160–174 2.74 0.04
H2-IAb 26–40 44–58 2.15 0.63
297–313 536–550 2.81 2.19
H2-IAd 21–35 374–388 0.34 0.67
168–182 539–553 1.22 0.18
H2-IEd 14–28 110–124 18.45 13.17
34–48 520–534 30.62 13.22
a

The immune epitope database (http://tools.immuneepitope.org/mhcii). The prediction was run three times.

b

H2-IAb, H2-IAd, and H2-IEd alleles are mouse MHC class II molecules; the HLA-DRB1*01:01 allele is a human MHC class II molecule.

c

We chose 15 amino acids for analysis each time.

d

Low percentile rank = high level binding, high percentile rank = low level binding, IC50 values = percentile rank.