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. 2016 Mar 31;4:e1884. doi: 10.7717/peerj.1884

Table 2. GO-dysregulated.

The top 15 up- and downregulated GO terms.

GO-ID GO-name Enrichment P-value
Upregulated GOs by GO analysis
GO:0043066 Negative regulation of apoptotic process 5.274431709 5.53034E−12
GO:0032496 Response to lipopolysaccharide 8.108054973 1.51933E−11
GO:0006954 Inflammatory response 8.099023444 2.11218E−10
GO:0007165 Signal transduction 5.49328365 2.53815E−10
GO:0071347 Cellular response to interleukin-1 16.88289078 1.09298E−08
GO:0045944 Positive regulation of transcription from RNA polymerase II promoter 3.652056561 1.27896E−08
GO:0014070 Response to organic cyclic compound 6.26379716 3.29652E−08
GO:0008285 Negative regulation of cell proliferation 5.262199724 5.94266E−08
GO:0033590 Response to cobalamin 90.04208417 6.01314E−08
GO:0042493 Response to drug 4.287718294 6.34324E−08
GO:0006468 Protein phosphorylation 4.846457788 8.88401E−08
GO:0042542 Response to hydrogen peroxide 12.4673655 1.76279E−07
GO:0009617 Response to bacterium 19.09983604 2.66E−07
GO:0001889 Liver development 8.612721094 2.86336E−07
GO:0001666 Response to hypoxia 5.58112092 4.40694E−07
Downregulated GOs by GO analysis
GO:0045893 Positive regulation of transcription, DNA-dependent 3.77523152 3.05206E−07
GO:0045892 Negative regulation of transcription, DNA-dependent 4.062477396 3.32485E−07
GO:0016568 Chromatin modification 13.26523231 5.79738E−07
GO:0043065 Positive regulation of apoptotic process 5.038731654 6.66823E−07
GO:0008150 Biological process 2.365931438 1.86723E−06
GO:0016572 Histone phosphorylation 46.4283131 3.08593E−06
GO:0045944 Positive regulation of transcription from RNA polymerase II promoter 2.954529015 4.94117E−06
GO:0006355 Regulation of transcription, DNA-dependent 2.982729366 6.6796E−06
GO:0003407 Neural retina development 36.11091019 1.08935E−05
GO:0001525 Angiogenesis 5.879901494 1.29214E−05
GO:0008284 Positive regulation of cell proliferation 3.559902873 3.26349E−05
GO:0006950 Response to stress 5.762379285 4.3047E−05
GO:0006915 Apoptotic process 3.631264712 4.68891E−05
GO:0007165 Signal transduction 3.448256676 8.82113E−05
GO:0043066 Negative regulation of apoptotic process 3.059606407 0.000134769