Table 3.

Hazard Ratio (95% Confidence Interval) of Incident Heart Failure by OSA Quartiles

	Minimally Adjusted*	MV Adjusted†	MV + WASO Adjusted†	MV + AF Adjusted†	MV + Hypoxemia Adjusted†	MV + Dropping Those with Baseline HF†	MV + Truncating Follow-up to Start of CPAP Use†
Quartile 1 (OAHI <6)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Quartile 2 (OAHI 6 to <12.5)	0.87 (0.53–1.44)	0.74 (0.44–1.23)	0.74 (0.44–1.25)	0.86 (0.51–1.46)	0.73 (0.43–1.22)	0.89 (0.52–1.53)	0.76 (0.45–1.29)
Quartile 3 (OAHI 12.5 to <23)	1.42 (0.90–2.25)	1.34 (0.84–2.13)	1.35 (0.84–2.15)	1.35 (0.82–2.22)	1.30 (0.80–2.14)	1.40 (0.85–2.31)	1.21 (0.74–1.97)
Quartile 4 (OAHI ≥23)	1.74 (1.12–2.70)	1.42 (0.90–2.24)	1.40 (0.88–2.23)	1.45 (0.88–2.38)	1.40 (0.83–2.36)	1.29 (0.78–2.15)	1.30 (0.79–2.12)

Definition of abbreviations: AF = atrial fibrillation; CPAP = continuous positive airway pressure; HF = heart failure; MV = multivariable; OAHI = obstructive apnea hypopnea index; OSA = obstructive sleep apnea; WASO = wake after sleep onset.

^*Adjusted for clinic site, age, race, and history of heart failure.

^†Adjusted for clinic site, age, race, BMI, history of coronary artery disease (myocardial infarction, angina, bypass surgery, and angioplasty), heart failure, stroke, diabetes, hypertension, smoking, alcohol use, and physical activity.