Table 2.

Multivariable Model 1 to Predict Early HFOV in 1,064 Patients with Worst OI ≥8.0 on Days 0–1

Variable	Odds Ratio (95% CI)*	P Value†
Age at PICU admission		0.01
6.00–17.99 yr	1.00
2.00–5.99 yr	1.23 (0.81–1.85)
2 wk–1.99 yr	1.66 (1.16–2.36)
PRISM III-12 score (one-point increase)	1.00 (0.99–1.02)	0.58
Worst OI on Days 0–1		<0.001
8.0–15.9	1.00
16.0–24.9	2.52 (1.86–3.40)
25.0–39.9	5.76 (3.61–9.18)
≥40.0	17.21 (10.03–29.52)
Cardiovascular dysfunction on Days 0–1	2.31 (1.64–3.24)	<0.001
Neurologic dysfunction on Days 0–1	1.50 (1.05–2.14)	0.03

Definition of abbreviations: CI = confidence interval; HFOV = high-frequency oscillatory ventilation; OI = oxygenation index; PICU = pediatric intensive care unit; PRISM III-12 = Pediatric Risk of Mortality III score from first 12 hours in the PICU.

^*Odds ratio >1 indicates higher risk of early HFOV.

^†P values were calculated using logistic regression accounting for PICU as a cluster variable using generalized estimating equations.