Table 2.

Brain regions where higher mean IL-6 levels are associated with accelerated cortical thinning with age.

Brain region	Peak coordinates
	Brodmann area	Cluster size (mm2)	x	y	z	Cluster p-value	Mean β-values (mm/yr)
Cortex of the subcentral gyrus (operculum) and sulci	43	837.33	67.0	−11.4	17.3	< .001	−.006
Temporal pole	38	647.73	35.9	13.7	−35.8	< .001	−.007
Cortex of the transverse frontopolar gyri and sulci	10	566.39	−23.8	51.7	3.0	< .001	−.005
Cortex in the calcarine sulcus	18	562.40	12.3	−69.0	15.2	< .001	−.003
Temporal pole	20	399.11	−46.9	−3.8	−30.9	< .001	−.005
Inferior temporal gyrus	20	252.40	56.5	−32.8	−18.1	< .006	−.006
Cortex of the cingulate gyrus and sulcus (medial-anterior)	32	236.58	9.1	9.2	40.0	< .011	−.006
Superior occipital gyrus	31	215.54	−23.6	−82.1	25.2	< .018	−.006
Opercular part of the inferior frontal gyrus	22	203.72	−52.6	9.2	−1.7	< .025	−.005

Note. All coordinates are given in Talairach space. The parcellations were obtained using Destrieux sulcogyral based atlas [42]. Negative x coordinates refer to cortex in the left hemisphere, and positive x coordinates to the right hemisphere. Criterion for significance was defined as clusters with a minimum of 200 vertex, p < 0.005 with an additional cluster threshold of p < 0.05.