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. Author manuscript; available in PMC: 2016 Jun 18.
Published in final edited form as: Expert Opin Drug Discov. 2015 Jun 18;10(9):991–1010. doi: 10.1517/17460441.2015.1058775

Figure 2. Approaches for rational targeting the Rho GTPase signaling module.

Figure 2

A: Inhibition of Rho GTPase activation by GEFs via disrupting Rho-GEF interactions. B: Enhancing the intrinsic GTPase activity or Rho-GAP interaction. There has been limited experimental evidence for this approach to date. C: Inhibition of effector activity or disrupting Rho-effector interactions. D: Impairment of a Rho GTPase intracellular localization by altering its post-translational lipid modifications.