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Model of how Importin α1 mediates Yki nuclear import. Schematic diagram of the regulation of Yki nuclear import. When Hippo signaling is on, the upstream kinase can phosphorylate Yki at its Ser-168, making Yki stay in the cytoplasm through binding with 14-3-3 (left); while when Hippo signaling is off, Importin α1 can bind Yki through its Arg-15, then bring Yki into the nucleus to induce target gene expression (right).
