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Integrins modulate the response of IGF1R to its ligand. HOS cells were transfected with siRNA non-targeting control (siControl) or siRNA directed at integrins β1 (siβ1) or β3 (siβ3) and then stimulated with 25 ng/ml of IGF1 for 10 min. Western blotting reveals that IGF1-induced phosphorylation IGF1R and downstream targets is diminished by knockdown of integrin β1 or β3.
