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. 2016 Apr 8;18:17. doi: 10.1186/s12968-016-0239-0

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© Jacobs et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Comparison of AIF computed from automatically detected LV pixels vs. a manually selected ROI. The selected regions and the AIF curve measured from them are shown in a. Note how the automatically selected region (red pixels) excludes approximately three darker pixels included in the manual ROI (green ring), and includes other bright pixels outside the ring. The automatic AIF, as a result, displays a higher peak value and upslope, while maintaining similar time to peak and full-width at half maximum. Correlation of the manual and automatic AIF curves is shown in b. Despite the high correlation indicated, the differences in peak signal intensity give the trend line a larger slope (>1)