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. 2016 Feb 26;170(4):2478–2493. doi: 10.1104/pp.15.01827

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Figure 12. — Fe deficiency-responsive signaling pathway. Fe deficiency stabilizes the BTS protein that interacts with bHLH104 and bHLH105. bHLH34, bHLH104, and bHLH105 can form homodimers or heterodimers to activate the transcription of bHLH38/39/100/101 and PYE. FIT interacts with bHLH38/39/100/101 to activate the transcription of FRO2 and IRT1. PYE regulates the expression of ZIF1 and NAS4 negatively. MYB10 and MYB72 regulate the expression of NAS4 positively. The induction of MYB10/72 by Fe deficiency is partially dependent on FIT; bHLH34/104/105 are required for the induction of FIT and MYB10/72.