Table 3.

Expression of target genes in uterus with significant differences between vehicle and TBBPA-treated rats

Tissue/Gene	Vehicle Mean	Vehicle SE	Vehicle Median	TBBPA Mean	TBBPA SE	TBBPA Median	Increase/Decrease	P-value (Mann-Whitney Rank Sum test)	P-value (2-tailed t-test)
Proximal Uterus
Ccnb1	1.18	0.24	0.98	1.92	0.46	1.29	↑	0.042	-
Cyp1b1	1.94	0.76	0.56	4.81	1.46	3.08	↑	0.006	-
Cyp11a1	1.37	0.35	1.08	0.98	0.31	0.43	↓	0.004	-
Esr1	1.03	0.08	na	1.16	0.08	na	↑	-	0.008
Esr2	1.33	0.28	1.41	0.79	0.11	0.74	↓	<0.001	-
Hsd17b4	1.04	0.11	1.08	1.23	0.06	1.26	↑	<0.001	-
Igf1	1.16	0.18	1.30	1.80	0.31	1.78	↑	<0.001	-
Ppara	1.03	0.08	1.03	1.30	0.15	1.19	↑	0.016	-
Thra	1.04	0.10	na	na	1.15	0.09	↑	-	0.049
Ttr	1.64	0.55	1.00	2.91	0.96	1.19	↑	0.029	-
Ugt1a1	1.06	0.12	1.08	2.59	0.76	1.28	↑	<0.001	-
Distal Uterus
Birc5	1.14	0.30	0.93	1.04	0.25	0.68	↓	0.036	-
Ccnd1	1.06	0.13	1.14	0.93	0.07	0.90	↓	0.026	-
Ccnd2	1.06	0.15	na	1.37	0.11	na	↑	-	<0.0001
Cdk1	1.09	0.20	0.98	0.70	0.14	0.48	↓	<0.001	-
Cdk4	1.07	0.16	0.93	1.26	0.10	1.26	↑	0.011	-
Cyp1b1	2.64	1.36	0.69	11.21	3.66	5.88	↑	<0.001	-
Cyp2b1	1.13	0.34	1.03	0.57	0.11	0.44	↓	0.002	-
Cyp11a1	1.27	0.35	1.02	1.11	0.38	0.49	↓	0.03	-
Esr1	1.03	0.09	na	1.22	0.10	na	↑	-	0.002
Esr2	1.95	0.94	0.97	2.96	0.61	2.76	↑	<0.001	-
Hsd17b2	3.54	1.36	3.33	1.35	0.61	0.06	↓	<0.001	-
Igf1	1.15	0.20	1.40	1.87	0.37	1.62	↑	0.008	-
Nr3c1	1.03	0.11	na	1.17	0.07	na	↑	-	0.013
Ppara	1.05	0.13	na	1.57	0.12	na	↑	-	<0.0001
Pparg	1.08	0.19	0.94	0.92	0.15	0.76	↓	0.032	-
Thra	1.05	0.14	na	1.34	0.17	na	↑	-	0.004
Thrb	1.63	0.54	1.06	2.13	0.27	2.37	↑	0.001	-
Ugt1a1	1.04	0.13	0.98	2.28	0.65	1.45	↑	0.001	-

na = not applicable for determining significance using the 2-tailed t-test