Frequency of gene mutations involved in common functional pathways. Genes included in common functional pathways: Splicing: SF3B1, SRSF2, ZRSR2, U2AF1/2. DNA methylation: TET2, DNMT3A, IDH1/2. Transcription: SETBP1, RUNX1, BCOR/BCORL1, ETV6, NPM1, CEBPA, GATA2. Chromatin Modification: ASXL1, SUZ12, EZH2, MLL, KDM6A. Receptor/Kinases: JAK2, FLT3, KIT. Cohesion: STAG2, SMC3, SIMC1, RAD21. RAS Pathway: KRAS/NRAS, CBL, NF1, PTPN11. RNA Helicase: DDX41, DDX54, DHX29. Tumor Suppressor: TP53, APC, WT1, PFH6.