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(A) Inhibition of GPER-1 by G36 results in reduction of cell proliferation in cell lines with high GPER-1 expression as shown by the MTT assay. (B and C) Western blot analysis demonstrating that inhibition (B) or siRNA mediated downregulation (C) of GPER-1 results in abrogation of MAPK phosphorylation and inhibition of the AKT/mTOR pathway, as well as in induction of apoptosis in MINO and GRANTA-519, whereas no effects are seen in MAVER.
