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. 2015 Nov;100(11):1376–1387. doi: 10.3324/haematol.2014.113852

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Figure 3. — Leukemia stem cells. Leukemia stem cells (LSC) in acute myeloid leukemia (AML; red), chronic myelogenous leukemia (CML; dark blue), B-cell acute lymphoblastic leukemia (B-ALL; green), chronic lymphocytic leukemia (CLL; pale blue), myelodysplastic syndrome (MDS; orange) and JAK2 V617F positive myeloproliferative neoplasia (MPN; yellow) interact with their bone marrow microenvironment via specific pathways. Specific details are provided in the text. SDF-1α: stromal-derived factor 1α; BMP: bone morphogenetic protein; BMPR: bone morphogenetic protein receptor; Gas6: growth-arrest-specific-gene 6; VEGF (A): vascular endothelial growth factor (A); SCF: stem cell factor; IL-8: interleukin-8; PlGF: placental growth factor; TPO: thrombopoietin; LIF: leukemia-inhibitory factor; PDGF: platelet-derived growth factor; Ang2: angiopoietin2; TGFβ: transforming growth factor β.