Table 2.
μCT Analyses of Trabecular Bone in Proximal Tibia
Group | BV/TV (%) | Tb.N (1/mm)a | Tb.Th (mm)a | Tb.Sp (mm)a |
---|---|---|---|---|
Vehicle | 27.16 ± 3.8 | 5.17 ± 0.5 | 0.07 ± 0.0062 | 0.2 ± 0.034 |
PTH | 37.52 ± 0.065* | 5.59 ± 0.36* | 0.081 ± 0.0077 | 0.17 ± 0.016 |
DCA | 24.88 ± 0.078** | 5.23 ± 0.4 | 0.067 ± 0.01 | 0.19 ± 0.017 |
PTH+DCA | 30.12 ± 0.037*** | 4.9 ± 0.38*** | 0.075 ± 0.0045 | 0.19 ± 0.17 |
Values are mean ± SD.
BV = bone volume; TV = total volume; Tb.N = trabecular number; Tb.Th = trabecular thickness; Tb.Sp = trabecular spacing; DCA = dichloroacetate.
Data obtained from 35 of 16-mm slices right below growth plate, n ≥ 8 for each group.
Statistically significant effects for PTH were determined by ANOVA.
Statistically significant effects for DCA were determined by ANOVA.
Statistically significant effects for DCA-PTH interaction were determined by ANOVA.