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Relation between stemness and TMZ sensitivity. (A) Sensitivity to TMZ of GBM CSCs grown under stem or differentiated conditions. The P values were determined by ANOVA with the Tukey's test and are indicated for each significant point (*: P < 0.05; **: P < 0.01; *** P < 0.001 vs differentiated cells). (B) mRNA expression levels of ABCB1, ABCC1, ABCG2 and KDM5A in GBM3 differentiated cells relative to the same cells grown under stem-permissive conditions determined by quantitative PCR.
