Table 1.
Available X-ray crystallographic structures of CDK6
| Description | Resolution (Å) | PDB Code |
|---|---|---|
| CDK6 - Vcyclin76 | 3.10 | 1JOW |
| CDK6 - Vcyclin - 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine109 | 2.90 | 4TTH |
| CDK6 - Vcyclin - Aminopurvalanol114 | 2.80 | 2F2C |
| CDK6 - Vcyclin - Fisetin117 | 2.90 | 1XO2 |
| CDK6 - Vcyclin - PD0332991114 | 3.00 | 2EUF |
| CDK6 - Kcyclin - p18INK4c 118 | 2.90 | 1G3N |
| CDK6 - {5-[4-(dimethylamino)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl}[2-(isoquinolin-4-yl)pyridin- 4-yl]methanone111 | 2.70 | 4EZ5 |
| CDK6 - 1H-benzimidazol-2-yl(1H-pyrrol-2-yl)methanone111 | 2.31 | 4AUA |
| CDK6 - 4-[3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(1-methylpiperidin-4-yl)pyrimidin-2-amine119 | 2.60 | 3NUP |
| CDK6 - 4-[5-chloro-3-(1-methylethyl)-1H-pyrazol- 4-yl]-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine119 | 2.70 | 3NUX |
| CDK6 - p16INK4a 83 | 3.40 | 1BI7 |
| CDK6 - p19INK4d74,83 | 1.90 | 1BLX |
| 2.80 | 1BI8 |