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. 2015 Nov 13;14(21):3389–3395. doi: 10.1080/15384101.2015.1093702

Figure 1.

Figure 1.

Schematic representation of the structural domains of BRCA2 showing the binding sites for its protein partners. The panels illustrate the established and suggested functions of BRCA2 in: (A) HR-mediated repair. (B) Protection of DNA replication forks. (C) D-loop extension at stalled replication forks. (D) R-loop metabolism. (E, F) Mitosis progression and cytokinesis. (G) Transactivation activity. The phase of the cell cycle is indicated in red. The color-coding of the binding sites in the scheme corresponds to the colors of the panels in which the proteins are involved. DBD, DNA binding domain; H, helical domain; NLS, nuclear localization signal; NES, nuclear export signal; OB, oligonucleotide/oligosaccharide binding fold; SAC, spindle assembly checkpoint; TAD, Transactivation domain; AR, Androgen receptor. Ac, acetylation; P, phosphorylation; Ub, ubiquitination.