Figure 1.

Schematic representation of the structural domains of BRCA2 showing the binding sites for its protein partners. The panels illustrate the established and suggested functions of BRCA2 in: (A) HR-mediated repair. (B) Protection of DNA replication forks. (C) D-loop extension at stalled replication forks. (D) R-loop metabolism. (E, F) Mitosis progression and cytokinesis. (G) Transactivation activity. The phase of the cell cycle is indicated in red. The color-coding of the binding sites in the scheme corresponds to the colors of the panels in which the proteins are involved. DBD, DNA binding domain; H, helical domain; NLS, nuclear localization signal; NES, nuclear export signal; OB, oligonucleotide/oligosaccharide binding fold; SAC, spindle assembly checkpoint; TAD, Transactivation domain; AR, Androgen receptor. Ac, acetylation; P, phosphorylation; Ub, ubiquitination.