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. 2016 Feb 16;6(4):973–986. doi: 10.1534/g3.115.025437

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Copyright © 2016 Gu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Variably methylated regions (VMRs) enrich for transcription factor binding sites in a tissue-specific manner. (A) Colocalization between all VMRs and transcription factor binding sites. Number of transcription factor binding peaks in each VMR were counted and the percentage of VMRs with 0, 1, 2, or 3 and more transcription factor binding peaks were calculated. Differential fold enrichment of functionally relevant transcription factor binding peaks in hypomethylated regions for (B) blood, (C) skin and breast, (D) breast, and (E) brain.