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. 2016 Feb 8;6(4):987–992. doi: 10.1534/g3.115.026518

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Copyright © 2016 Sun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Functional impairment of mutated HAND2 in activation of a target gene. A dual-luciferase reporter assay was used to evaluate the functional consequence of the HAND2 mutation in a cellular context of HEK293 cells, showing that the mutant HAND2 was associated with significantly diminished transcriptional activation of the ANF promoter. Three independent experiments were carried out in triplicate, with mean and SD shown. ** denotes t = 14.3905, p = 0.0001; * indicates t = 6.6623, p = 0.0026, when compared with wild-type HAND2.