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. 2016 Feb 8;6(4):987–992. doi: 10.1534/g3.115.026518

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Copyright © 2016 Sun et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Impaired synergistic activation between HAND2 and GATA4 as well as NKX2.5 due to the mutation. The functional effect of the mutant HAND2 protein on cooperative activation of the ANF promoter with GATA4 or NKX2.5 was tested in HeLa cells, showing that the mutant HAND2 had significantly decreased activation of the reporter in synergy with GATA4 as well as NKX2.5. Experiments were conducted in triplicate, with mean and SDs shown. ** indicates t = 13.4046, p = 0.0002; * indicates t = 9.3988, p = 0.0007, when compared with wild-type counterparts.