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. 2016 Feb 8;6(4):993–1012. doi: 10.1534/g3.116.027904

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Copyright © 2016 Hoggard et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Deep mutational scanning of the HMR-E and HML-E silencer miniARSs-defined nucleotides required for their competitive fitness. (A) The data for a library of miniARS317-mut fragments was graphed to indicate the individual nucleotide substitutions that affected the competitive fitness of miniARS317-full. (B) As in 2A except data are from a miniARS301-mut experiment. (C) Detailed analyses of the mutational profile of the RAP1 (Rap1 protein binding site) sites. A consensus RAP1 site derived from genome-wide chromatin immunoprecipitation data are shown above the profiles. FKH, forkhead; ORC, origin recognition complex; YHP1, Yeast Homeo-Protein; SPT2, SuPpressor of Ty’s.