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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: Cell. 2015 Jun 4;161(6):1388–1399. doi: 10.1016/j.cell.2015.05.014

Figure 7. A Proposed Model of Translation Promotion by YTHDF1.

Figure 7

(A) YTHDF1 recruits m6A-modified transcripts to facilitate translation initiation. The association of YTHDF1 with translation initiation machinery may be dependent on the loop structure mediated by eIF4G and the interaction of YTHDF1 with eIF3.

(B) The m6A-based regulation through binding of YTHDF1 and YTHDF2 shares similarities with that of the AU-rich element which is regulated by HuR/ HuD and AUF1.