Extended Data Table 4. Histological report of patients with chronic pancreatitis.

The histopathological report is listed for the 15 patients with chronic pancreatitis in the discovery cohort.

Patient No.	PanIN described	Histopathological report
1	No	Pancreatic tissue with chronic pancreatitis and extensive fibrosis and focal necrosis lipolytic and triptolytic areas.
0	No	Diffuse periductal lymphoplasmacytic infiltrates; severe periductal fibrosis and duct obstruction/disappearance; severe interlobular and acinar involvement; severe inflammatory storiform fibrosis and diffuse sclerosis; frequent venulitis and occasional arteritis; scattered and occasionally prominent lymphoid follicles
3	No	Chronic pancreatitis with periductal, inter- and intralobular fibrosis
4	No	Chronic pancreatitis and extensive fibrosis
5	No	Chronic recurrent and acute pancreatitis with plurifocal tryptolytic and lipolytic necrosis
6	No	Low-grade chronic pancreatitis with periductal fibrosis, in the present material no evidence of neoplastic events, no evidence of malignancy.
7	No	Chronic recurrent pancreatitis with some more pronounced fibrosis and intraductal calcifications. Chronic pancreatitis extends to the pancreas resection margin.
8	No	Chronic pancreatitis, cholangitis and papillitis with focally histomorphological aspect of an autoimmune, chronic sclerosing pancreatitis.
9	PanIN 1a	Pancreatic parenchyma (head of the pancreas) and peripancreatic fat and connective tissue with chronic recurrent pancreatitis with some areas fibrosis and abscesses. Pancreatic intraepithelial neoplasia (PanIN) Grade 1A.
10	No	Pancreatic parenchyma with perilobular fibrosis as well as dilated pancreatic ducts. In addition, peripancreatic fat and connective tissue with fibrosis. The finding represents a chronic pancreatitis.
11	PanIN 1a	Chronic-recurrent pancreatitis with pronounced fibrosis and dilated pancreatic ducts with focal inflammatory reactive epithelial cells. Older areas of organized necrosis and focal pancreatic intraepithelial neoplasia (PanIN) Grade 1A. Chronic pancreatitis also affects the pancreas resection margin.
12	No	Pancreatitis with focally accentuated, periductal, perilobular and intralobular fibrosis as well as smaller areas of organized fatty necrosis and presence of singel giant cells of foreign body type.
13	No	Chronic recurrent and acute pancreatitis with plurifocal tryptolytic and lipolytic necrosis with extensive destruction of the pancreatic parenchyma. Smaller secretion - and obliteration of pancreatic ducts with periductal fibrosis and localized squamous metaplasia. Peri- and interlobular fibrosis of the pancreatic parenchyma. Pancreatitis reaches the resection margin. At present, no neoplastic tissue, no evidence of malignancy.
14	No	Pancreatic tissue with some scarring chronic inflammation and chronic pancreatits. In the present material, no evidence of malignancy.
15	No	Tumor -free pancreatic tissue (surgical margins) with low periductal and interlobular fibrosis.