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Model for the MTOC switch. In a mitotic cell, SPD-2 is modified and centrosome reactivation as the MTOC is CDK-dependent. In an interphase or differentiated cell, SPD-2 is unmodified and the centrosome is inactivated as an MTOC. Upon fusing a mitotic and interphase/differentiated cell, mitotic SPD-2 is recruited to the interphase centrosome, which is then activated as the MTOC.
