Figure 3.

MALT1 is dispensable for γ-H2AX cryptic foci formation. (A) Immunodetection of BCL10 and γ-H2AX in T47D cells transfected with control siRNA (CTL siRNA), or MALT1 siRNA (MALT1 siRNA). Quantification of the average number of cryptic γ-H2AX foci per cells is shown on the right. MALT1 knocking down efficiency was shown by an immunoblot on the top. (B) The effect of BCL10 knock down on NFκB activation in response to DNA damage. NFκB activation was measured by the translocation of p65 into the nucleus in response to DNA damage with or without BCL10 depletion. Quantification of the p65 nuclear translocation was measured.