Figure 1.

Rapid screening for anti-breast cancer antibiotics using Biolog Phenotype Microarrays. Representative micrographs of Phenotype Microarray analyses measuring tetrazolium dye reduction by MDA-MB-231, SUM-159PT, and JIMT-1 breast carcinoma cells cultured in the absence or presence of 92 antibiotics and other growth inhibitors. Red boxes denote highly active drugs in which at least 3 of the 4 graded concentrations decreased optical density by ≥50 % in each individual cell line. Drug names labeled in red denote those drugs exhibiting high activity in all 3 breast cancer cell lines.