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Summary of the number and type of mutations identified in Erk5-/-VavCre compared to a heterozygote control Erk5+/-VavCre mouse.
| A. Total mutations identified | |||
|---|---|---|---|
| Type of mutation | Erk5−/− | Erk5+/− | Increased in Erk5−/− |
| Non-synonymous | 1149 | 103 | 11 |
| Exon | 1135 | 102 | 11 |
| Stop codon | 9 | 1 | 9 |
| Splicing | 5 | 0 | 5 |
| Synonymous | 2398 | 144 | 17 |
| Total | 3547 | 247 | 14 |
