Table 1.
Differentially expressed genes (DEGs) with a fold change (FC) cutoff > 2.0 and adjusted p values < 0.05
| Gene title term | Gene ontology term | Gene Symbol | FC | Padj |
|---|---|---|---|---|
| transmembrane protein 221 | integral component of membrane | Tmem221 | −87.46 | 6.78E–52 |
| ENSRNOG00000045967 | unknown | unknown | −75.01 | 6.71E–14 |
| similar to Glutathione S-transferase A1 | Glutathione transferase activity | GSTA6 | −74.77 | 0.00104 |
| ENSRNOG00000045691 | unknown | unknown | −47.64 | 5.89E–05 |
| ENSRNOG00000017412 | unknown | unknown | −42.43 | 0.0058 |
| ribosomal protein L28-like | structural constituent of ribosome | RGD1565183 | −16.22 | 0.013 |
| ENSRNOG00000030351 | unknown | unknown | −14.96 | 2.5E–10 |
| ENSRNOG00000033517 | unknown | unknown | −13.24 | 0.021 |
| ENSRNOG00000030548 | Unknown | unknown | −10.41 | 5.59E–12 |
| nitric oxide synthase 2, inducible | arginine binding | NOS2 | −8.83 | 0.0067 |
| RT1 class I, locus CE4 | peptide antigen binding | RT1-CE4 | −8.73 | 0.0099 |
| ENSRNOG00000031667 | unknown | unknown | −8.57 | 0.021 |
| Osteopontin | extracellular matrix binding | Spp1 | −8.57 | 4.38E–13 |
| NLR family, apoptosis inhibitory protein 2 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | Naip2 | −7.33 | 0.033 |
| ENSRNOG00000029389 | unknown | unknown | −6.89 | 0.0011 |
| SNRPN upstream reading frame protein-like | ubiquitin-protein transferase activity | Snurf | −6.86 | 1.48E–11 |
| neuropeptide VF precursor | receptor binding | Npvf | −6.6 | 0.0089 |
| ENSRNOG00000031454 | unknown | unknown | −6.56 | 0.02 |
| family with sequence similarity 3, member B | unknown | Fam3b | −6.31 | 0.035 |
| ENSRNOG00000032578 | unknown | unknown | −6.24 | 0.026 |
| patatin-like phospholipase domain containing 1 | lipid metabolic process | Pnpla1 | −5.75 | 0.0028 |
| coiled-coil domain containing 152 | unknown | Ccdc152 | −5.42 | 0.021 |
| Family with sequence similarity 70, member B | unknown | Tmem255b | −5.28 | 0.01 |
| thrombospondin 4 | calcium ion binding | Thbs4 | −5.11 | 0.034 |
| lumican | extracellular space | Lum | −4.74 | 0.01 |
| Cerebroside sulfotransferase | galactosylceramide sulfotransferase activity | Gal3st1 | −4.67 | 0.022 |
| phosphodiesterase 4D, cAMP-specific | 3′,5′-cyclic-AMP phosphodiesterase activity | Pde4d | −4.61 | 0.00055 |
| matrilin 3 | proteinaceous extracellular matrix | Matn3 | −4.48 | 0.01 |
| carbonic anhydrase 9 | carbonate dehydratase activity | Car9 | −4.14 | 0.011 |
| ENSRNOG00000033957 | unknown | unknown | −3.93 | 0.003 |
| ENSRNOG00000017661 | unknown | unknown | −3.86 | 0.003 |
| fibrinogen-like 2 | peptidase activity | Fgl2 | −3.83 | 4.23E–05 |
| Tp53rk binding protein | tRNA processing | TPRKB | −3.7 | 0.00098 |
| STEAP family member 4 | cupric reductase activity | Steap4 | −3.57 | 4.43E–05 |
| ENSRNOG00000029070 | unknown | unknown | −3.57 | 0.018 |
| ligase IV, DNA, ATP-dependen | DNA ligase (ATP) activity | Lig4 | −3.46 | 7.49E–19 |
| gremlin 1, DAN family BMP antagonist | transmembrane receptor protein tyrosine kinase activator activity | GREM1 | −3.44 | 0.0015 |
| myosin VIIb | ATP binding | Myo7b | −3.331 | 0.012 |
| family with sequence similarity 129, member A | negative regulation of protein phosphorylation | Fam129a | −3.26 | 0.036 |
| wingless-type MMTV integration site family, member 16 | frizzled binding | Wnt16 | −3.05 | 0.031 |
| interferon induced transmembrane protein 1 | integral component of membrane | Ifitm1 | −2.88 | 0.0033 |
| retinol saturase (all trans retinol 13,14 reductase) | all-trans-retinol 13,14-reductase activity | Retsat | −2.87 | 1.81E–11 |
| EGF-like module containing, mucin-like, hormone receptor-like 1 | calcium ion binding | Emr1 | −2.86 | 0.00076 |
| cellular retinoic acid binding protein 1 | retinal binding | Crabp1 | −2.85 | 5.2E–18 |
| ENSRNOG00000039025 | unknown | unknown | −2.84 | 0.012 |
| coiled-coil domain containing 146 | unknown | Ccdc146 | −2.8 | 9.9E–05 |
| BAI1-associated protein 2-like 1 | proline-rich region binding | Baiap2l1 | −2.71 | 8.3E–06 |
| sodium channel, voltage-gated, type VII, α | sodium channel activity | Scn7a | −2.64 | 0.031 |
| zinc finger protein 182-like | metal ion binding | Zfp943 | −2.62 | 7.96E–05 |
| family with sequence similarity 65, member C | unknown | Fam65c | −2.59 | 3.2E–11 |
| ENSRNOG00000032997 | unknown | unknown | −2.56 | 0.046 |
| ENSRNOG00000039790 | unknown | unknown | −2.56 | 0.00045 |
| YME1-like 1 (S. cerevisiae) | ATP binding | Yme1l1 | −2.54 | 5.51E–10 |
| solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | amino acid transmembrane transporter activity | Slc7a11 | −2.53 | 0.0013 |
| Slc24a5 solute carrier family 24, member 5 | calcium, potassium:sodium antiporter activity | Slc24a5 | −2.53 | 0.0049 |
| Cd48 molecule | antigen binding | Cd48 | −2.51 | 0.037 |
| cubilin (intrinsic factor-cobalamin receptor) | calcium ion binding | Cubn | −2.49 | 0.0018 |
| coiled-coil domain containing 80 | heparin binding | Ccdc80 | −2.48 | 0.032 |
| mitochondrially encoded NADH 4L | NADH dehydrogenase (ubiquinone) activity | MT-ND4L | −2.46 | 7.58E–07 |
| phospholipase A2, group IIC | extracellular region | Pla2g2c | −2.37 | 0.023 |
| advillin | actin binding | Avil | −2.35 | 5.62E–05 |
| CGRP receptor component | DNA-directed RNA polymerase activity | Crcp | −2.35 | 9.8E–14 |
| asparaginase like 1 | asparaginase activity | Asrgl1 | −2.34 | 5.6E–06 |
| testis expressed 15 | fertilization | Tex15 | −2.33 | 4.23E–05 |
| zinc finger protein 420-like | metal ion binding | Zfp677 | −2.27 | 0.0012 |
| bone morphogenetic protein 6 | BMP receptor binding | Bmp6 | −2.25 | 0.0032 |
| disabled 2, mitogen-responsive phosphoprotein | phosphatidylinositol 3-kinase binding | Dab2 | −2.25 | 0.0098 |
| calcitonin receptor-like | adrenomedullin receptor activity | Calcrl | −2.23 | 0.035 |
| HAUS augmin-like complex, subunit 1 | cell division | Haus1 | −2.22 | 1.67E–07 |
| lysyl oxidase | carbohydrate binding | Lox | −2.21 | 0.0033 |
| sterile α motif domain containing 9-like | common myeloid progenitor cell proliferation | Samd9l | −2.2 | 0.0065 |
| hypothetical LOC300751 | unknown | RGD1311874 | −2.15 | 0.033 |
| zinc finger protein 873 | metal ion binding | Zfp873 | −2.16 | 0.013 |
| myosin IC | actin-dependent ATPase activity | Myo1c | −2.11 | 4.88E–08 |
| inositol (myo)-1(or 4)-monophosphatase 2 | inositol monophosphate 1-phosphatase activity | Impa2 | −2.10 | 0.0012 |
| cadherin 19, type 2 | calcium ion binding | Cdh19 | −2.09 | 0.007 |
| ENSRNOG00000048784 | unknown | unknown | −2.08 | 1.42E–06 |
| regulator of telomere elongation helicase 1 | ATP-dependent DNA helicase activit | Rtel1 | −2.07 | 2.19E–10 |
| diacylglycerol kinase, gamma | ATP binding | Dgkg | −2.06 | 0.035 |
| similar to Centromeric protein E (CENP-E protein) | unknown | Ccdc175 | −2.05 | 0.00989 |
| DNA primase, p49 subunit | DNA primase activity | Prim1 | −2.02 | 1.12E–06 |
| phosphoribosyl pyrophosphate synthetase 2 | ADP binding | Prps2 | −2.00 | 0.013 |