Table 3.
Cell death gene ontology (GO) terms for differentially expressed genes (DEGs) and additional related genes according to GeneMANIA analysis for each category (20 days, 3 months, and 18 months)
| GO annotation | Genes/Total number of genes | p value |
|---|---|---|
| 20 days | ||
| GO:0097191 extrinsic apoptotic signaling pathway | 13/200 | 3.53e–11 |
| GO:0051402 neuron apoptotic process | 12/218 | 1.77e–9 |
| GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand | 7/73 | 1.43e–6 |
| GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 6/75 | 3.21e–5 |
| GO:2001234 negative regulation of apoptotic signaling pathway | 7/151 | 6.94e–5 |
| GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors | 5/56 | 1.7e–4 |
| GO:2001235 positive regulation of apoptotic signaling pathway | 5/123 | 2.93e–3 |
| GO:0008637 apoptotic mitochondrial changes | 4/90 | 1.14e–2 |
| GO:0090199 regulation of release of cytochrome c from mitochondria | 3/37 | 1.45e–2 |
| 3 months | ||
| GO:0043525 positive regulation of neuron apoptotic process | 6/52 | 1.82e–5 |
| GO:0070266 necroptotic process | 5/26 | 2.13e–5 |
| GO:0097193 intrinsic apoptotic signaling pathway | 8/215 | 1.26e–4 |
| GO:0097191 extrinsic apoptotic signaling pathway | 8/200 | 8.73e–5 |
| GO:0097194 execution phase of apoptosis | 4/60 | 7.24e–3 |
| GO:0097300 programmed necrotic cell death | 5/32 | 4.3e–5 |
| GO:0008637 apoptotic mitochondrial changes | 4/90 | 2.4e–2 |
| GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors | 4/56 | 5.89e–3 |
| GO:1901214 regulation of neuron death | 7/217 | 1.19e–3 |
| GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 9/179 | 1.02e–5 |
| 18 months | ||
| GO:0051402 neuron apoptotic process 15/218 | 6.2e–13 | |
| GO:0070997 neuron death | 15/253 | 1.45e–12 |
| GO:0097191 extrinsic apoptotic signaling pathway | 10/200 | 3.06e–7 |
| GO:0097194 execution phase of apoptosis | 3/60 | 3.64e–2 |
| GO:0008637 apoptotic mitochondrial changes | 4/90 | 1.09e–2 |
| GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process | 5/179 | 1.25e–2 |
| GO:0070265 necrotic cell death | 3/39 | 1.44e–2 |
| GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator | 3/60 | 3.64e–2 |