20 days |
1 |
Pten, Rasa1, Hgf, Ets1, Kitlg, Ednrb |
Regulation of signaling by interleukins (Il-2 and Il-7) and signal transduction EGFR, VEGF, FGFR, insulin receptor, NGF, PDGF, SCF-KIT, ERBB2, ERBB4, PIP3 activates AKT signaling, signaling by BMP, signaling by TGF-β receptor complex, signaling by GPCR; inositol phosphate metabolism and metabolism of lipids and lipoproteins and axon guidance. |
2 |
Rock1, Erbb3, Tgfbr1, Tgfb2, Rb1cc1 |
apoptotic execution phase, CaM pathway, calmodulin induced events, immune system and signal transduction. |
3 |
Fas, Btg2, Dnajb9, Cdkn1b, Tgfa, Ngf, Sycp3, Igf1 |
Caspase-8 activation by cleavage, FasL/CD95L signaling, regulation by c-FLIP, innate immune system. |
3 months |
1 |
Lig4, Ccl6, Tns4, Tp63, Casp8, Pdcd4, Casp12, Casp4, Casp7, cFlar,Birc3 |
TRAIL signaling, death receptor signaling, regulation by c-Flip, Caspase-8 activation by cleavage and dimerization of procaspase-8 |
2 |
Casp1, Cdk1, Litaf, Cryab, Sgk1, Pawr, Ripk3, Cd24, Nfkbia |
the role of DCC in the regulation of apoptosis and the execution phase of apoptosis |
3 |
Fgf2, Lgals7, Grk1, Alox15, Alox12 |
metabolism of lipids and lipoproteins (regulation of the metabolism of arachidonic acid) |
18 months |
1 |
Hspa1b, Nqo1, Mal, Ptprc, Anxa1, Sphk1, Ctnna1, Adrb2, Cdh1, Erbb2, Actn4, Casp7 |
FasL/CD95L signaling, TRAIL signaling, regulation of apoptosis by c-FLIP, in caspase 8 and procaspase 8 dimerization in the apoptotic pathways, and the regulation of the immune system |
2 |
Hspb1, Phlda3, Il1rn, Erbb3, Ntf3, Fgfr3, Bcl2l10, Adipoq |
apoptotic cleavage of cellular proteins (apoptotic execution phase), activation, myristolyation of BID and translocation to mitochondria, apoptotic factor-mediated response (cytochrome c-mediated apoptotic response and SMAC-mediated apoptotic response) in intrinsic pathway and caspase-8 activation by cleavage and dimerization of procaspase-8. |
3 |
Alox12, Sh3glb1, Lig4, Bard1, Cdk1, Cd24, Perp, Nuak2, Tgfa |
integration of energy metabolism, transmission across chemical synapses, potassium channels in neuronal system, signaling by NGF. |
4 |
Ripk2, Myd88, Ngfr, Casp8, Chek2 |
regulation of innate immune system and metabolism of lipids and lipoproteins. |