Table 4.
Cluster analysis of gene networks for 20-day-old, 3-month-old and 18-month-old rats. Showing clusters with the number of nodes more than 3
| Cluster | Genes | Biological processes |
|---|---|---|
| 20 days | ||
| 1 | Pten, Rasa1, Hgf, Ets1, Kitlg, Ednrb | Regulation of signaling by interleukins (Il-2 and Il-7) and signal transduction EGFR, VEGF, FGFR, insulin receptor, NGF, PDGF, SCF-KIT, ERBB2, ERBB4, PIP3 activates AKT signaling, signaling by BMP, signaling by TGF-β receptor complex, signaling by GPCR; inositol phosphate metabolism and metabolism of lipids and lipoproteins and axon guidance. |
| 2 | Rock1, Erbb3, Tgfbr1, Tgfb2, Rb1cc1 | apoptotic execution phase, CaM pathway, calmodulin induced events, immune system and signal transduction. |
| 3 | Fas, Btg2, Dnajb9, Cdkn1b, Tgfa, Ngf, Sycp3, Igf1 | Caspase-8 activation by cleavage, FasL/CD95L signaling, regulation by c-FLIP, innate immune system. |
| 3 months | ||
| 1 | Lig4, Ccl6, Tns4, Tp63, Casp8, Pdcd4, Casp12, Casp4, Casp7, cFlar,Birc3 | TRAIL signaling, death receptor signaling, regulation by c-Flip, Caspase-8 activation by cleavage and dimerization of procaspase-8 |
| 2 | Casp1, Cdk1, Litaf, Cryab, Sgk1, Pawr, Ripk3, Cd24, Nfkbia | the role of DCC in the regulation of apoptosis and the execution phase of apoptosis |
| 3 | Fgf2, Lgals7, Grk1, Alox15, Alox12 | metabolism of lipids and lipoproteins (regulation of the metabolism of arachidonic acid) |
| 18 months | ||
| 1 | Hspa1b, Nqo1, Mal, Ptprc, Anxa1, Sphk1, Ctnna1, Adrb2, Cdh1, Erbb2, Actn4, Casp7 | FasL/CD95L signaling, TRAIL signaling, regulation of apoptosis by c-FLIP, in caspase 8 and procaspase 8 dimerization in the apoptotic pathways, and the regulation of the immune system |
| 2 | Hspb1, Phlda3, Il1rn, Erbb3, Ntf3, Fgfr3, Bcl2l10, Adipoq | apoptotic cleavage of cellular proteins (apoptotic execution phase), activation, myristolyation of BID and translocation to mitochondria, apoptotic factor-mediated response (cytochrome c-mediated apoptotic response and SMAC-mediated apoptotic response) in intrinsic pathway and caspase-8 activation by cleavage and dimerization of procaspase-8. |
| 3 | Alox12, Sh3glb1, Lig4, Bard1, Cdk1, Cd24, Perp, Nuak2, Tgfa | integration of energy metabolism, transmission across chemical synapses, potassium channels in neuronal system, signaling by NGF. |
| 4 | Ripk2, Myd88, Ngfr, Casp8, Chek2 | regulation of innate immune system and metabolism of lipids and lipoproteins. |