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Rap1 knockout reduced NFκB-dependent cytokines in pro-inflammatory phenotypic macrophages. mRNA expression of LPS-induced (5ng/ml, 4 hours) NFκB-dependent genes in (A) peritoneal; (B) bone marrow-derived M1; (C) and bone marrow-derived M2 macrophages isolated from Rap1+/+ and Rap1−/− mice. mRNA levels are expressed as fold changes against those mRNA expression in Rap1+/+ macrophages with no stimulation. Data are shown as means ± SEM #P <0.05 Rap1+/+ vs. Rap1−/−; n = 6.
