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. 2015 Oct 27;14(23):3698–3712. doi: 10.1080/15384101.2015.1104436

Figure 1.

Figure 1.

Spinal cord injury induces up-regulation of E2F1 and E2F2 transcription factors. (A-B) Expression of E2F1 and E2F2 mRNA in the mouse injured spinal cord was elevated at 6 and 24 hours after SCI. n=3-4 mice per time point. (C) Representative immunoblots for E2F1, E2F2, and the loading control (β-actin). (D-E) Expression levels of E2F1 and E2F2 protein were normalized by GAPDH, as estimated by optical density measurements, and expressed as a fold of sham spinal cord. Quantification of western blot showed significantly increased E2F1 and E2F2 expression at 24 hours post-injury. n=4-5 mice per group. *p < 0.05, **p < 0.01, ***p < 0.001 versus sham group.