Skip to main content
. 2015 Oct 27;14(23):3698–3712. doi: 10.1080/15384101.2015.1104436

Figure 7.

Figure 7.

E2F1-2 ablation improves motor functional recovery and limits hyperesthesia after SCI. (A) Basso Mouse Scale (BMS) locomotor scores were significantly improved up to 6 weeks post-SCI in E2Fdko (E2F1-2 double ko) mice as compared to the wild-type (WT) controls. Deletion of E2F2 did not affect BMS scores. n=10 (WT), 8 (E2Fdko), 5 (E2F2ko) mice. *p < 0.05, **p < 0.01, versus WT group. (B) E2Fdko mice significantly decreased grid walk errors at 4 weeks after SCI. n=6 (WT), 6 (E2Fdko), 5 (E2F2ko) mice. *p < 0.05 vs. WT group. (C) E2Fdko mice increased stride length of the hindlimbs at weeks 4 post-injury. n=6 (WT), 6 (E2Fdko), 5 (E2F2ko) mice. *p < 0.05 versus WT mice. (D) Von Frey mechanical test. No significant difference in withdrawal threshold was found in sham groups between the genotypes. On day 28 after SCI, the E2Fdko mice had a higher mechanical threshold than the WT mice. n=5 mice/group. *p < 0.05 vs. sham/WT mice; #p < 0.05 versus SCI/WT mice. (E-F) Thermal test. SCI caused increased thermal sensitivity in WT mice, whereas E2Fdko mice had similar thermal withdrawal threshold compared to sham uninjured mice. n=5 mice/group. *p < 0.05 vs. sham/WT mice; #p < 0.05 versus SCI/WT mice.