Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
mTOR regulates the SASP. In senescent cells, mTOR regulates the SASP by controlling the translation of IL1A and MAPKAPK2. MAPKAPK2 phosphorylates and inhibits the RNA-binding protein ZFP36L1, thereby preventing the degradation of SASP transcripts by ARE-mediated decay. Additionally, IL1α activates NF-κB in a cell-autonomous manner to promote the transcription of SASP genes. Upon mTOR inhibition, ZFP36L1 degrades SASP transcripts and the IL1α feedback loop is abrogated.
