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. 2015 Dec 4;15(1):117–127. doi: 10.1080/15384101.2015.1121326

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 5. — Tetraploidization of senescent hMESCs induced by Ku application. (A) hMESCs were left untreated (Ctr-control) or were treated either with H₂O₂ alone or in presence of the inhibitor and analyzed by FACS at indicated time points. The percentage of cells with DNA content > 4n is given. Representative FACS analyses are shown. (B) Quantification of tetraploidy induced by Ku. hMESCs were treated and analyzed as in (A). M ± SD, N = 3, ***p<0.005, versus control, §§§p<0.005, versus H₂O₂-treated cells, ns – not significant (Ctr – control). (C) Viability of the Ku-induced tetraploid cells. hMESCs were treated as in (A), then cells were reseeded in 5 d, additionally cultured for 7 d and analyzed by FACS. M ± SD, N = 3, ***p<0.005, versus control, §p<0.05, versus H₂O₂-treated cells. Ctr – control.