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. Author manuscript; available in PMC: 2016 Apr 8.
Published in final edited form as: Science. 2015 Aug 7;349(6248):650–655. doi: 10.1126/science.aab0983

Fig. 3. Identification of TDP-43–associated cryptic exons (Homo sapiens).

Fig. 3

(A) TDP-43 protein levels are greatly reduced when HeLa cells are treated with TDP-43 siRNA (asterisk indicates nonspecific band). (B) Visualization of the cryptic exon located in EPB41L4A. Zoom-in of gene annotation demonstrates that the cryptic exon (green arrow) resides in a nonconserved region. Strand-specific analysis also verifies the incorporation of cryptic exons on the transcribing strand (fig. S12). (C to F) IRF9 contains a transcriptional start site (C), KRT7 contains an exon extension (D), GPSM2 contains a standard cryptic exon (E), and INSR contains a polyadenylation site (F). (G) UG repeats are also found adjacent to human cryptic exons.