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HDL-inspired delivery platforms fall broadly into three categories: natural HDL itself, discoidal HDL analogs (termed reconstituted HDL or rHDL), and spheroidal HDL analogs. Payloads that have been tested include small molecules and oligonucleotides.
| Small Molecules | Oligonucleotides | |
|---|---|---|
| Natural HDL | 6, 40-42 | |
| Discoidal HDL | 55-63 | 99, 100 |
| Spherical HDL | 72, 73, 75-77 | 35, 38, 79, 81-83 |
