Table 2.

Characterization of the JNK signaling pathway effectors required for rbf1^D253A-induced apoptosis and overgrowth phenotypes.

		Adult stage (wing)		Larval stage (wing imaginal disc)
Rbf1D253A		Notch phenotype	Overgrowth phenotype	Quantification of apoptosis
Transcription factors	jra IA109	Rescue n= 417, α = 3.5 10–4, Ws=-3.56	Rescue n= 511, α = 3.74 10–2	Decrease n= 52, α<10–30
	UAS-RNAi-kay	Rescue n= 417, α = 1.1 10–11, Ws=-7.04	Rescue n= 417, α = 0.86 10–2	Decrease n= 45, α<10–30
JNKK	UAS-RNAi-hep	Rescue n= 348, α = 6.7 10–7, Ws=-5.01	Rescue n= 384, α<10–30	Decrease n= 47, α<10–30
	UAS-RNAi-mkk4	No effect n= 207, α = 0.4, Ws=-0.90	No effect n= 212, α = 0.49	No effect n= 51, α = 0.53
JNKKK	UAS-RNAi-dtak1	Rescue n= 198, α = 1.1 10–8, Ws=-5.82	Rescue n= 252, α<10–30	Decrease n= 56, α<10–30
	UAS-RNAi-dASK1	No effect n= 354, α = 8.8 10–2, Ws=-2.61	No effect n= 370, α = 0.48	No effect n= 41, α = 0.78
	UAS-RNAi-slipper	Enhancement n= 272, α = 6.0 10–6, Ws = 4.54	Rescue n= 294, α = 4.33 10–2	No effect n= 40, α = 0.23
	UAS-RNAi-dmekk1	Rescue n= 352, α = 2.2 10–6, Ws=-4.76	Rescue n= 372, α = 1.19 10–2	Decrease n= 38, α<10–30
Adaptator proteins	UAS-RNAi-dtraf1	Enhancement n= 327, α = 8.1 10–4, Ws = 3.34	Rescue n= 357, α<10–30	No effect n= 53, α = 0.42
	UAS-RNAi-dtraf2	No effect n= 279, α = 0.5, Ws = 0.64	No effect n= 336, α = 0.39	No effect n= 46, α = 0.17
	UAS-RNAi-rac1	Rescue n= 625, α = 3.4 10–9, Ws=-6.03	Rescue n= 708, α<10–30	Decrease n= 49, α<10–30
	dsh 1	No effect n= 434, α = 4.0 10–3, Ws=-2.87	No effect n= 476, α = 0.34	No effect n= 40, α = 0.60
	UAS-RNAi-tab2	No effect n= 461, α = 1 10–2, Ws=-2.47	No effect n= 505, α = 0.27	No effect n= 36, α = 0.91