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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Virology. 2016 Feb 11;491:79–88. doi: 10.1016/j.virol.2016.01.015

Table 1.

Experimental design and group assignments for all three studies.

Treatment group Source of MDA Challenge strain or vaccine typea N Indirect contacts (N)
Study 1
No MDA/NC None None 9 -
No MDA/H1N2 None H1N2-δ1(1:7)b 10 5
WIV-MDA/H1N2 WIV H1N2-δ1(1:7) 10 5
No MDA/H1N1 None H1N1pdm09(2:6)b 10 5
WIV-MDA/H1N1 WIV H1N1pdm09(2:6) 10 5
Study 2
No MDA/NC None None 9 -
No MDA/H1N1 None H1N1pdm09(2:6) 8 5
WIV-MDA/H1N1 WIV H1N1pdm09(2:6) 8 5
EXP-MDA/H1N1 Experimental infectiona H1N1pdm09(2:6) 8 5
No MDA/H1N2 None H1N2-δ1(1:7) 8 5
WIV-MDA/H1N2 WIV H1N2-δ1(1:7) 8 5
EXP-MDA/H1N2 Experimental infectionc H1N2-δ1(1:7) 8 5
NAT-MDA/H1N2 Natural infectionc H1N2-δ1(1:7) 8 -
Study 3
No MDA/WIV None WIV 2 -
WIV-MDA/WIV WIV WIV 7 -
No MDA/COM None Commercial 2 -
WIV-MDA/COM WIV Commercial 7 -
a

Challenge strains for Studies 1&2, vaccine type for Study 3.

b

H1N2-δ1(1:7) = virus containing HA from A/swine/Minnesota/02011/08 H1N2 δ1 and the other seven genes from A/turkey/Ohio/313053/04 H3N2; H1N1pdm09(2:6)= virus containing the surface genes from A/California/04/2009 H1N1 and the other six genes from A/turkey/Ohio/313053/04 H3N2.

c

EXP-MDA pigs suckled sows which were previously naturally exposed and then experimentally boosted with live exposure to H1N1pdm09 and NAT-MDA pigs suckled sows which were previously naturally exposed to H1N1pdm09 only.