Table 1.

Genes associated with neurodegenerative disease pathogenesis.

Neurodegenerative Disease	Gene	Function
Parkinson Disease *adapted from Verstraeten et al. 2015 [1]	SNCA (PARK1)	Encodes a-synuclein, the primary component in Lewy bodies [14]
	PARK2	E3 ubiquitin ligase, protein degradation [15]
	PINK1 (PARK6)	Serine/threonine kinase, stress-induced mitochondrial response [15]
	DJ-1 (PARK7)	Antioxidant and oxidative stress sensor [15]
	LRRK2 (PARK8)	Leucine-rich repeat kinase 2, scaffold protein function. Overall function unknown [15]
	ATP13A2 (PARK9)	Lysosomal transmembrane ATPase protein, necessary for lysosomal function [16]
	PLA2G6 (PARK14)	Encodes iPLA2-VI, cell membrane homeostasis [18]
	FBXO7 (PARK15)	F-box-containing protein, protection of neurons and apoptosis inhibitor [17]
	VPS35 (PARK17)	Subunit of retromer complex, involved in Golgi endosomal transport [19]
	EIF4G1 (PARK18)	Eukaryotic translation initiation factor 4-gamma 1, translation initiation [20]
	DNAJC6	Encodes auxilin, synaptic vesicle recycling [21]
	ATP6AP2	(Pro)renin receptor, glucose metabolism [22]
	COQ2	Ubiquinone, mitochondrial electron transport chain [23]
	SYNJ1	Encodes synaptojanin 1, synaptic vesicle recycling [21]
	DNAJC13	Regulation of endosomal clathrin coats [24]
Alzheimer’s Disease *adapted from Vilatela et al. 2012 [25]	APP	Transmembrane protein, amyloid plaques in AD [26]
	PSEN1	Component of gamma-secretase, cleaves APP [26]
	PSEN2	Component of gamma-secretase, cleaves APP [26]
	APOE	Glycoprotein, cholesterol distribution [26]
Huntington’s disease	Huntingtin	Aggregation leads to neurodegeneration [27]