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The kynurenine pathway. 1: tryptophan dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO), 2: formamidase, 3: kynurenine aminotransferase, 4: kynurenine-3-monooxygenase (KMO), 5: kynureninase, 6: kynurenine aminotransferase, 7: kynureninase, 8: 3- hydroxyanthranilic acid dioxygenase, 9: quinolinic acid phosphoribosyltransferase.
